2-methoxy-6-methylpyridine-3-carboxylic acid
2-Methoxy-6-methylnicotinic acid
CAS: 72918-10-6
Molecular Formula: C8H9NO3
2-methoxy-6-methylpyridine-3-carboxylic acid - Names and Identifiers
| Name | 2-Methoxy-6-methylnicotinic acid |
| Synonyms | 2-Methoxy-6-methylnicotinic acid 2-methoxy-6-methylpyridine-3-carboxylic acid 3-Pyridinecarboxylic acid, 2-methoxy-6-methyl- |
| CAS | 72918-10-6 |
2-methoxy-6-methylpyridine-3-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C8H9NO3 |
| Molar Mass | 167.16 |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD11982968 |
2-methoxy-6-methylpyridine-3-carboxylic acid - Risk and Safety
| Hazard Class | IRRITANT |
2-methoxy-6-methylpyridine-3-carboxylic acid - Introduction
2-Methoxy-6-methylnicotinic acid is an organic compound whose chemical formula is C8H9NO3. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 2-Methoxy-6-methylnicotinic acid is a white crystalline solid.
-Melting point: about 153-155 degrees Celsius.
-Solubility: It can be dissolved in alcohol, chloroform and dimethylformamide, and slightly soluble in water.
Use:
2-Methoxy-6-methylnicotinic acid has many applications in the field of medicine:
-It is an intermediate for the synthesis of certain drugs and can be used to synthesize antibacterial and antiviral drugs.
-It is also used as a protective group of drugs to improve the pharmacokinetic properties and bioavailability of drugs.
Preparation Method:
The preparation method of 2-Methoxy-6-methylnicotinic acid is complex and involves multi-step reactions. One of the commonly used synthetic routes is as follows:
1. First, 3-methoxyethyl ester and nicotinic acid are reacted under alkaline conditions to produce 3-methoxy-6-carboxy nicotinic acid.
2. Then, in the presence of sulfuric acid, 3-methoxy-6-carboxynicotinic acid was subjected to methyl esterification reaction to obtain 2-Methoxy-6-methylnicotinic acid.
Safety Information:
Security information for 2-Methoxy-6-methylnicotinic acid is not publicly available. However, since it is an organic compound, the following safety precautions should be taken:
-During operation, use appropriate personal protective equipment, such as lab gloves and goggles.
-Avoid contact with skin and eyes.
-should be in a well ventilated place to operate, avoid inhalation of its vapor.
-Ensure that waste is disposed of correctly and in accordance with relevant regulations.
Please note that the specific use and preparation of this compound may require more detailed evaluation and handling by a specialized laboratory or manufacturing facility.
Nature:
-Appearance: 2-Methoxy-6-methylnicotinic acid is a white crystalline solid.
-Melting point: about 153-155 degrees Celsius.
-Solubility: It can be dissolved in alcohol, chloroform and dimethylformamide, and slightly soluble in water.
Use:
2-Methoxy-6-methylnicotinic acid has many applications in the field of medicine:
-It is an intermediate for the synthesis of certain drugs and can be used to synthesize antibacterial and antiviral drugs.
-It is also used as a protective group of drugs to improve the pharmacokinetic properties and bioavailability of drugs.
Preparation Method:
The preparation method of 2-Methoxy-6-methylnicotinic acid is complex and involves multi-step reactions. One of the commonly used synthetic routes is as follows:
1. First, 3-methoxyethyl ester and nicotinic acid are reacted under alkaline conditions to produce 3-methoxy-6-carboxy nicotinic acid.
2. Then, in the presence of sulfuric acid, 3-methoxy-6-carboxynicotinic acid was subjected to methyl esterification reaction to obtain 2-Methoxy-6-methylnicotinic acid.
Safety Information:
Security information for 2-Methoxy-6-methylnicotinic acid is not publicly available. However, since it is an organic compound, the following safety precautions should be taken:
-During operation, use appropriate personal protective equipment, such as lab gloves and goggles.
-Avoid contact with skin and eyes.
-should be in a well ventilated place to operate, avoid inhalation of its vapor.
-Ensure that waste is disposed of correctly and in accordance with relevant regulations.
Please note that the specific use and preparation of this compound may require more detailed evaluation and handling by a specialized laboratory or manufacturing facility.
Last Update：2024-04-09 21:04:16
